Tipanat 20 (Trifluridine / Tipiracil) 20 mg

Approved for the treatment of adult patients with:

• 🎗️ Metastatic Colorectal Cancer (mCRC): Who have been previously treated with standard chemotherapy (fluoropyrimidine, oxaliplatin, irinotecan).
• 🎗️ Metastatic Gastric Cancer: Including adenocarcinoma of the gastroesophageal junction, after at least two prior lines of chemotherapy.

Packaging: Bottle of 20 Tablets (20 mg / 8.19 mg).

⚠️ DOSING SCHEDULE (28-Day Cycle):

• 🧮 Calculation: The dose is strictly calculated based on Body Surface Area (BSA).
• 📅 Regimen: Typically taken twice daily on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
• 🍽️ With Food: Must be taken within 1 hour after completion of morning and evening meals. Taking it on an empty stomach reduces effectiveness. Swallow whole with water.

• Severe renal or hepatic impairment.
• Pregnancy and breastfeeding (embryo-fetal toxicity).
• Hypersensitivity to Trifluridine or Tipiracil.

Monitoring is crucial due to bone marrow suppression:

• 📉 Myelosuppression: Severe neutropenia (risk of sepsis), anemia, and thrombocytopenia. Complete blood counts (CBC) must be monitored prior to and during the cycle.
• 🤢 Gastrointestinal: Nausea, vomiting, decreased appetite, diarrhea.
• 😴 Fatigue: Asthenia and extreme tiredness are very common.