Pazonat (Pazopanib) 400 mg

Indicated for the treatment of adults with:

• 🎗️ Advanced Renal Cell Carcinoma (RCC): Kidney cancer that has spread or relapsed.
• 🦴 Advanced Soft Tissue Sarcoma (STS): For patients who have received prior chemotherapy (specifically for subtypes where efficacy is proven).

Standard Dosage: 800 mg (Two 400 mg tablets) once daily.

⚠️ CRITICAL SAFETY WARNING:

• 🚫 Take on an EMPTY STOMACH only.
• ⏰ Timing: At least 1 hour before or 2 hours after a meal.
• Reason: Taking this drug with food increases absorption dangerously, leading to toxicity.

💊 Do not crush: Swallow tablets whole. Crushing increases the rate of absorption and risk of side effects.

• Severe hepatic impairment.
• Pregnancy and breastfeeding (teratogenic effects).
• Gastrointestinal fistula or severe bleeding risk.

Monitoring is essential:

• 🦁 Hair Depigmentation: Hair color may turn white or grey. This is a common, non-harmful side effect.
• 📉 Hepatotoxicity: Elevated liver enzymes (ALT/AST). Frequent blood tests are mandatory.
• Hypertension: High blood pressure.
• Diarrhea, fatigue.